Publications

2017

Wellman SM, Kozai TDY. Understanding the inflammatory tissue reaction to brain implants to improve neurochemical sensing performance. ACS Chemical Neuroscience. [LINK] [Request Link up to 50 reads]

Salatino JW, Ludwig KA, Kozai TDY, Purcell EK. Glial responses to implanted electrodes in the brain. 2017 Nature Biomedical Engineering. 2017. 1. 862-877. [LINK] [Read only Link]

Wellman SM, Eles JR, Ludwig KA, Seymour J, Michelson NJ, McFadden WE, Vazquez AL, Kozai TDY. A Materials Roadmap to functional Neural Interface Design. Advanced Functional Materials. [LINK
Special Issue: "Advanced Functional Materials Solutions to Engineering the Neural Interface"

Du Z, Kolarcik CL, Kozai TDY, Luebben SD, Sapp SA, Zheng XS, Nabity JA, Cui XT. Ultrasoft microwire neural electrodes improve chronic tissue integration. Acta Biomaterialia. 2017. 53, 46-58.  [LINK]

Eles JR, Vazquez AL, Snyder NR, Lagenaur C, Murphy MC, Kozai TDY*, Cui XT*. Neuroadhesive L1 coating attenuates acute microglial attachment to neural electrodes as revealed by live two-photon microscopy. Biomaterials. 2017. 113. 279-292.  [LINK]

2016

Khilwani R, Gilgunn PJ, Kozai TDY, Ong XC, Korkmaz E, Gunalan P, Cui XT, Fedder GK, Ozdoganlar OB. Ultra-Miniature Ultra-Compliant Neural Probes with Dissolvable Delivery Needles: Design, Fabrication and Characterization. Biomedical Microdevices. 18(6), 97. [LINK]

Patel PR, Zhang H, Robbins M, Nofar J, Marshal S, Kobylarek M, Kozai TDY, Kotov NA, Chestek C. Chronic in vivo stability assessment of carbon fiber microelectrode arrays J Neural Eng. 2016. 13(6). 066022. [LINK]

Kozai TDY, Jaquins-Gerst AS, Vazquez AL, Michael AC, Cui XT. Dexamethasone retrodialysis attenuates microglial response to implanted probes in vivo. Biomaterials. 2016. 87, 157-169 [LINK]

Kozai TDY, Eles JR, Vazquez AL, Cui XT. Two-photon imaging of chronically implanted neural electrodes: Sealant methods and new insights. J Neurosci Meth. 2016. 258, 46-55 [LINK]

Kozai TDY, Catt K, Du Z, Na K, Srivannavit O, Haque RM, Seymour J, Wise KD, Yoon E, Cui XT. Chronic in vivo evaluation of PEDOT/CNT for stable neural recordings. IEEE TBME. 2016. 63(1), 111-119 (DOI: 10.1109/TBME.2015.2445713) [LINK

2015

Alba NA, Du Z, Catt, K, Kozai TDY, Cui XT. In vivo electrochemical analysis of a PEDOT/MWCNT neural electrode. Biosensors. 2015,5(4),618-646. [LINK]

Kolarcik CL, Luebben SD, Sapp SA, Hanner J, Snyder N, Kozai TDY, Chang E, Nabity JA, Nabity ST, Lagenaur CF, Cui XT. Elastomeric and soft conducting microwires for implantable neural interfaces. Soft Matter. 2015. 11, 4847-4861. [LINK]

Patel PR, Na K, Zhang H, Kozai TDY, Kotov NA, Yoon E, Chestek CA. Insertion and development of linear 8.6μm diameter channel carbon fiber electrode arrays for single unit recordings. J Neural Eng. 2015. 12 (4), 046009. [LINK]

Kozai TDY, Vazquez AL. Photoelectric artefact from optogenetics and imaging on microelectrodes and bioelectronics: New Challenges and Opportunities. J Materials Chemistry B. 2015. 3. 4965 – 4978. [LINK] (Cover)

Kozai TDY, Jaquins-Gerstl A, Vazquez AL, Michael AC, Cui XT. Brain Tissue Responses to Neural Implants Impact Signal Sensitivity and Intervention Strategies. ACS Chemical Neuroscience. 2015. 6(1). 48-67. [LINK] (Cover)

Kozai TDY, Du Z, Gugel ZV, Smith MA, Chase SM, Bodily LM, Caparosa EM, Friedlander RM, Cui XT. Comprehensive Chronic Laminar Single-Unit, Multi-Unit, and Local Field Potential Recording Performance with Planar Single Shank Electrode Arrays. Journal of Neuroscience Methods. 2015. 242. 15-40. [LINK]

Kozai TDY, Catt K, Li X, Gugel ZV, Olafsson VT, Vazquez AL, Cui XT. Mechanical failure modes of chronically implanted planar silicon-based neural probes for laminar recording. Biomaterials. 2015. 37. 25-39. [LINK]

Kolarcik CL, Catt K, Rost E, Albrecht I, Bourbeau D, Du Z, Kozai TDY, Luo X, Weber DJ, Cui XT. Evaluation of poly(3,4-ethylenedioxythiophene)/carbon nanotube neural electrode coatings for stimulation in the dorsal root ganglion. J Neural Eng. 2015. 12. 016008.
[LINK]

2014

Kozai TDY, Li X, Bodily LM, Caparosa EM, Zenonos GA, Carlisle DL, Friedlander RM, Cui XT. Effects of caspase-1 knockout on chronic neural recording quality and longevity: Insight into cellular and molecular mechanisms of the reactive tissue response. Biomaterials. 2014. 35(36). 9620-9634. [LINK]

Kozai TDY, Gugel ZV, Li X, Gilgunn PJ, Khilwani R, Ozdoganlar OB, Fedder GK, Weber DJ, Cui XT. Chronic tissue response to carboxymethyl cellulose based dissolvable insertion needle for ultra-compliant, ultra-small neural probes. Biomaterials. 2014. 35(34). 9255-68. [LINK]

Kozai TDY, Alba NA, Zhang H, Kotov NA, Gaunt RA, Cui XT. “Nanostructured coatings for improved charge delivery to neurons” in “Nanotechnology and Neuroscience: nano-electronic, photonic, and mechanical neuronal interfacing” Springer. 2014. [LINK]
 
2012

Kozai TDY, Langhals NB, Patel PR, Deng X, Zhang H, Lahann J, Kotov N, Kipke DR. Ultrasmall implantable composite microelectrodes with bioactive surfaces for chronic neural interfaces. Nature Materials. 2012 11(12), 1065-1073. [LINK] (ToC Image)

Kozai TDY, Vazquez AL, Weaver CL, Kim SG, Cui XT. In vivo two photon microscopy reveals immediate microglial reaction to implantation of microelectrode through extension of processes. J Neural Eng. 2012. 9. 066001. [LINK]

Gilgunn PJ, Khilwani R, Kozai TDY, Weber DJ, Cui XT, Erdos G, Ozdoganlar OB, Fedder GK. An ultra-compliant, scalable neural probe with molded biodissolvable delivery vehicle. Micro Electro Mechanical Systems (MEMS), IEEE 25th International Conference on 2012, 56-59. [LINK]

2010

Kozai TDY, Marzullo TC, Langhals NB, Hooi FM, Majewska AK, Brown EB, Kipke DR. Reduction of neurovascular damage resulting from microelectrode insertion into cerebral cortex using in vivo two-photon mapping. Journal of Neural Engineering. J. Neural Eng. 2010. 7. 046011. [LINK]

2009

Kozai TDY
, Kipke DR; Insertion Shuttle with Carboxyl Terminated Self-Assembled Monolayer Coatings for Implanting Flexible Polymer Neural Probes in the Brain. Journal of Neuroscience Methods. Nov 15, 2009. 184(2). 199-205. [LINK]

Escamilla–Mackert T, Langhals NB, Kozai TDY, Kipke DR. Insertion of a Three Dimensional Silicon Microelectrode Assembly through a Thick Meningeal Membrane. 31st Annual International IEEE EMBS Conference. September 3-6, 2009, Minneapolis, MN, USA. 1616-1618. [LINK]