"The most cited paper from 2015 thus far, is a review article from Kozai
and co-workers at the University of Pittsburgh and the McGowan Center
for Regenerative Medicine entitled “Brain tissue responses to neural
implants impact signal sensitivity and intervention strategies” (DOI: 10.1021/cn500256e).(2)
This review was in the biannual special issue on Monitoring Molecules,
edited by Prof. Anne Andrews. The review focused on the complex
molecular and cellular changes that occur when a device breaches the
blood-brain barrier and is implanted. The review does a fantastic job
summarizing the magnitude, variability, and time course (of acute,
seconds to minutes, and chronic, week to months) of injuries and
responses to the introduction of foreign bodies into the brain. The
review ends with reflections on how and deeper understanding of these
complex issues might lead to devices with improved sensitivity and
longevity.(2) This is truly a must read." http://pubs.acs.org/doi/10.1021/acschemneuro.7b00246 |
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