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Lehong Li

EDUCATION AND TRAINING:

MD. Peking University, Medical School  China
MS. Cytology and Histology, Basic Science Department, Academy of Traditional Chinese Medicine, China
Post Doctor Fellow, Department of Physiology, University of Pennsylvania, USA
Visiting Scientist, Sichuan Medical Research Scholarship, Department of Pathology, Kyoto Medical University, JAPAN

CERTIFICATION:

Educational Commission For Foreign Medical Graduate (ECFMG) Certificate, 0-699-8272 USA, 2012


SELECTED PUBLICATIONS:

 α-Synuclein binds the K(ATP) channel at insulin-secretory granules and inhibits insulin secretion.
Geng X, Lou H, Wang J, Li L, Swanson AL, Sun M, Beers-Stolz D, Watkins S, Perez RG, Drain P. Am J Physiol Endocrinol Metab. 2011 Feb;300(2):E276-86. 

Antidiabetic sulfonylurea stimulates insulin secretion independently of plasma membrane KATP channels.
Geng X, Li L, Bottino R, Balamurugan AN, Bertera S, Densmore E, Su A, Chang Y, Trucco M, Drain P. Am J Physiol Endocrinol Metab. 2007 Jul;293(1):E293-301. 

Ligand-dependent linkage of the ATP site to inhibition gate closure in the KATP channel.
Li L, Geng X, Yonkunas M, Su A, Densmore E, Tang P, Drain P.
J Gen Physiol. 2005 Sep;126(3):285-99.

Concerted gating mechanism underlying KATP channel inhibition by ATP.
Drain P, Geng X, Li L.
Biophys J. 2004 Apr;86(4):2101-12.

The insulin secretory granule is the major site of K(ATP) channels of the endocrine pancreas.
Geng X, Li L, Watkins S, Robbins PD, Drain P.
Diabetes. 2003 Mar;52(3):767-76.

Imaging secretory vesicles by fluorescent protein insertion in propeptide rather than mature secreted peptide.
Watkins S, Geng X, Li L, Papworth G, Robbins PD, Drain P.
Traffic. 2002 Jul;3(7):461-71.

Open state destabilization by ATP occupancy is mechanism speeding burst exit underlying KATP channel inhibition by ATP.
Li L, Geng X, Drain P.
J Gen Physiol. 2002 Jan;119(1):105-16.

The I182 region of Kir6.2 is closely associated with ligand binding in KATP channel inhibition by ATP. 
Li L, Wang J, Drain P.
Biophysical Journal. 2000:79:841-852.

K-ATP channel inhibition by ATP requires distinct functional domains of the cytoplasmic C-terminus of the pore-forming subunit. 
Drain P, Li L, Wang J.
Proc. Natl. Acad. Sci. 1998. 95, 13953-13958.